77779193永利-yl23455永利

    Background:  

     This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein 

     with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle

     progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles

     between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. 

     Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.