Product Description
| Description | Anti- Rab3A Rabbit Polyclonal Antibody |
| Another Name | Anti- Rab3A Rabbit Polyclonal Antibody |
| Catalog Number | NL24014 |
| Size: | 100 µl |
| Tested Applications: | ELISA WB IHC ELISA:1:1000-1:5000 WB:1:500-1:2000 IHC：1：100-1：300 |
| Cited Applications: | ELISA WB IHC |
| Tested Reactivity: | Human , mouse |
| Full Name | RAB3A, member RAS oncogene |
| Gene Symbol: | RAB3A |
| Immunogen : | Fusion protein of human RAB3A |
| Concentration: | 1mg/ml |
| Host/Isotype: | Rabbit/IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Predicted mv: | 25KDa |
| Observed mv: | 25KDa |
| Uniprot: | p20336 |
| Constituents: | PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Storage Conditions: | Store at -20°C for one year after shipment |
Background: | Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMe |
