77779193永利-yl23455永利

    Background:  

    The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways 

    that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. 

    This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1

    mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this

    protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich 

    syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene 

    results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5,

    7, 8 and 20.