77779193永利-yl23455永利

    Background:  

    Small GTPases are a super-family of cellular signaling regulators. Cdc42 belongs to the Rho sub-family of GTPases 

    that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Cdc42, and the 

    hydrolysis of GTP to GDP renders it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while 

    exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs).