Background:  

    Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal 

    adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin 

    contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation.

    Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT 

    cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes 

    gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, 

    which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration

    and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important 

    role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and 

   CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the

   localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.