Background:  

    ADP-ribosylation factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras 

    superfamily, with 20 kDa protein size. ARFs bind and regulate GTP/GDP cycle by alternating between the 

    active GTP-boundand inactive GDP-bound conformations. ARF family proteins are essential and ubiquitous 

    in eukaryotes. Six highly conserved members of the family have been identified in mammalian cells. They 

    function in vesicular traffic and actin remodelling and other bioprocesses in cells. The ARF6 is one of best

    identified ARFs It is present at the plasma membrane and to some extent on endosomal membranes where 

    it regulates the flow of trafficking into and out of the cell and the actin cytoskeleton. The antibody is specific to

    ARF6.