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| 价格： | ￥3800.00 |
| 品牌： | NEWLF  |
| 货号： | NL25080 |
| 规格： | 100ul |
Product Description
| Description | Anti-Braf (V600E) Mouse Monoclonal Antibody |
| Another Name | Anti-Braf (Mutated V600E) Mouse Monoclonal Antibody |
| Catalog Number | NL25080 |
| Size: | 100 µl |
| Tested Applications: | ELISA WB IF IHC ELISA:1:500-1:1000 WB:1:500-1:1000 IF:1:100-1:200 IHC:1:50-1:200 |
| Cited Applications: | WB IF IHC |
| Tested Reactivity: | Human , mouse Rat |
| Cited Reactivity: | Human , mouse Rat |
| Gene Symbol: | NS7; B-raf; BRAF1; RAFB1; B-RAF1 |
| Immunogen : | A synthetic peptide from the internal region of human BRAF which includes the mutation of V600E |
| Concentration: | 1mg/ml |
| Host/Isotype: | mouse/IgG2b |
| Class: | monnoclonal |
| Type: | Antibody |
| Predicted mv: | 84KDa |
| Observed mv: | 84KDa |
| Uniprot: | p15056 |
| Constituents: | PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Storage Conditions: | Store at -20°C for one year after shipment |
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Background: |
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.
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Tested Applications: WB
Tested Applications: IF
Tested Applications: IHC